The Application of Solution Calorimetry to Quantify Amorphous Lactose Occurring at 10% w/w or less

Introduction The processing of crystalline pharmaceuticals is often responsible for introducing small amounts of amorphous material. This disorder often occupies only a small percentage of the total mass, and is thus apparently insignificant. However it is capable of affecting that material’s behaviour since it resides primarily on the particle surface, making that surface predominantly amorphous and consequently altering interfacial interactions.